Greespi in the Daily Diet of People with Parkinson's Disease.

Greespi in the Daily Diet of People with Parkinson's Disease: Mechanisms of Neuroprotection and Oxidative Stress Reduction

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the gradual destruction of dopamine-producing nerve cells in the brain. This leads to impaired motor functions, tremors, rigidity, and bradykinesia (slowness of movement). The key factor in PD progression is the death of dopaminergic neurons located in the substantia nigra of the brain. The main pathogenic mechanisms include oxidative stress, neuroinflammation, and the accumulation of abnormal proteins such as α-synuclein. These protein aggregates can cause toxic effects and stimulate neuronal death (Hernández et al., 2017).

Oxidative stress, i.e., the formation of reactive oxygen species (ROS), is a major factor contributing to neuronal destruction in PD. Free radicals can damage cellular structures, including membranes, proteins, and DNA, leading to neuronal death. Additionally, the accumulation of abnormal α-synuclein aggregates activates microglia—immune cells in the brain—triggering chronic neuroinflammation, which exacerbates neuronal damage.

Nutrition Enriched with Greespi

Due to its bioactive components, Greespi is a beneficial dietary supplement for people with Parkinson’s disease. The foundation of Greespi is fresh-frozen microalgae. Freezing preserves powerful antioxidants and other vital compounds in an active state.

Consumption of Greespi can significantly support the body of individuals with PD through several mechanisms:

1. Antioxidant Protection

Oxidative stress is one of the main factors leading to neuronal death in PD. Free radicals damage brain cells, accelerating disease progression. Antioxidants in Greespi (phycocyanin, β-carotene, vitamin E, and phenolic compounds) neutralize these radicals, reducing oxidative stress levels and protecting neurons from damage. This contributes to overall improvement and slows disease progression.

2. Anti-Inflammatory Effect

Brain inflammation is a crucial factor in the advancement of PD. Microglia, which normally protect the brain, can become overactive and produce inflammatory molecules (cytokines) that harm neurons. Greespi helps reduce these molecules due to the presence of gamma-linolenic acid (GLA). GLA regulates microglial activity, lowering the synthesis of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), thus reducing inflammation and potentially slowing neuronal degeneration.

3. Enhancement of Energy Metabolism

Mitochondria are the "powerhouses" of cells, generating energy in the form of ATP. In PD, mitochondria often malfunction, leading to a deficit in neuronal energy supply. Greespi contains bioactive compounds that improve mitochondrial efficiency, increasing ATP levels. This ensures neurons receive the necessary energy for proper functioning, aiding in the preservation of motor functions and slowing disease progression.

4. Neuroprotective Action

Greespi stimulates the production of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), which is essential for neuronal survival, growth, and development. This helps neurons remain healthy, which is crucial for PD patients, as it slows cognitive decline. Additionally, the amino acids, vitamins, and minerals in Greespi support neuronal energy metabolism and stability.

5. Improvement of Psycho-Emotional State

Many PD patients suffer from depression and anxiety disorders. Greespi contains amino acids and trace elements that promote the synthesis of serotonin and dopamine, neurotransmitters that enhance mood and overall emotional well-being.

The Role of Diet in Parkinson’s Disease

A balanced diet is a crucial aspect of maintaining health in PD. A diet rich in fruits, vegetables, whole grains, legumes, and lean meats contributes to overall well-being. Greespi is a powerful tool for gut health support due to its polysaccharides, which improve microbiome balance and reduce constipation—a common issue among PD patients.

Interaction with Medications

PD treatments such as carbidopa-levodopa may be poorly absorbed if taken immediately after a protein-rich meal. To maximize the benefits of Greespi, it is recommended to consume it separately from medications.

Currently, no medications can completely cure Parkinson’s disease. Therapy focuses on symptom relief and slowing disease progression. Incorporating Greespi as part of functional nutrition is an effective tool for improving the quality of life for people with PD.

Greespi supports neuroprotection, reduces oxidative stress and inflammation, and enhances energy metabolism, which may contribute to slowing disease progression and alleviating symptoms. Use 1-2 servings according to the instructions here.

Bioactive Components in Greespi

Phycocyanin

Phycocyanin is a pigment that gives microalgae their characteristic color. To test Greespi, leave a few green drops in a glass for half a day—by evening, they will turn blue. Phycocyanin is a powerful antioxidant that neutralizes free radicals and reduces oxidative stress, a key factor in neuronal damage in Parkinson’s disease. Phycocyanin also has anti-inflammatory properties, which are essential for reducing neuroinflammation.

Beta-Carotene

Beta-carotene is a provitamin that converts into vitamin A in the body. It is a strong antioxidant that helps protect neurons from oxidative stress-related damage. Beta-carotene supports brain function and may reduce the risk of neurodegenerative diseases such as Parkinson’s.

Vitamin E

Vitamin E is another powerful antioxidant that decreases oxidative stress in the brain and protects cells from damage. It also improves circulation, which is essential for neuronal health, and supports the normal function of the nervous system.

Gamma-Linolenic Acid (GLA)

GLA is a polyunsaturated fatty acid with potent anti-inflammatory properties. It may help reduce chronic brain inflammation characteristic of Parkinson’s disease and lower microglial activity, preventing additional neuronal damage.

Minerals (Iron, Magnesium, Calcium)

Greespi is rich in essential minerals that support normal nervous system function. Iron is necessary for oxygen transport to brain cells, magnesium helps reduce spasms and tension in nerve cells, and calcium supports normal neurotransmitter activity.

Amino Acids (Glutamine, Leucine)

The amino acids in Greespi are vital for neuronal energy metabolism. Glutamine and leucine contribute to neuronal stability and function, supporting their normal operation and viability.

Polysaccharides

Greespi contains polysaccharides that support gut health, reduce inflammation, and enhance immune response. Since Parkinson’s disease is linked to neuroinflammation, maintaining a healthy microbiome may help prevent or mitigate symptoms.

Sources:

Fernandes, R., Campos, J., Serra, M., Fidalgo, J., Almeida, H., Casas, A., Toubarro, D., & Barros, A. I. R. N. A. (2023). Exploring the Benefits of Phycocyanin: From Spirulina Cultivation to Its Widespread Applications. Pharmaceuticals. 

2.       Bermejo-Bescós, P., Piñero-Estrada, E., & Villar del Fresno, Á. M. (2008). Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron-induced toxicity in SHSY5Y neuroblastoma cells. Toxicology in Vitro, 22(6), 1496–1502.

3.       Béraud, D., Hathaway, H. A., Trecki, J., Chasovskikh, S., Johnson, D. A., Johnson, J. A., Federoff, H. J., Shimoji, M., Mhyre, T. R., Maguire-Zeiss, K. A., & Federoff, H. J. (2012). Microglial Activation and Antioxidant Responses Induced by the Parkinson’s Disease Protein α-Synuclein. Journal of Neuroimmune Pharmacology, 8(1), 94–117.

4.        Chen, J. C., Liu, K. S., Yang, T. J., Hwang, J. H., Chan, Y. C., & Lee, I. Te. (2012). Spirulina and C-phycocyanin reduce cytotoxicity and inflammation-related genes expression of microglial cells. Nutritional Neuroscience, 15(6), 252–256.